DEVELOPMENTAL IMMUNOHISTOCHEMISTRY OF THE 22 KDA PEROXISOMAL MEMBRANE-PROTEIN IN THE HUMAN BRAIN

Authors
MIYAWAKI T SOHMA O SUZUKI Y TAKASHIMA S
Citation
T. Miyawaki et al., DEVELOPMENTAL IMMUNOHISTOCHEMISTRY OF THE 22 KDA PEROXISOMAL MEMBRANE-PROTEIN IN THE HUMAN BRAIN, Brain research, 700(1-2), 1995, pp. 285-288
Citations number
19
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
700
Issue
1-2
Year of publication
1995
Pages
285 - 288
Database
ISI
SICI code
0006-8993(1995)700:1-2<285:DIOT2K>2.0.ZU;2-J
Abstract
We studied immunohistochemically the 22 kDa peroxisomal membrane prote in (PMP 22). In the control brain, the immunopositive neurons for PMP 22 appeared 2-3 weeks earlier than those for peroxisomal enzymes. PMP 22-immunopositive glial cells appeared at 26-27 gestational weeks, inc reased with gestational age, and were rarely recognized after 1 year o f age. In the patients with Zellweger syndrome, PMP 22-immunoreactivit y was recognized in neurons, glias, liver and kidney cells.