Biophoton emission or spontaneous ultraweak light emission has been ob
served from almost all living organisms, with intensities ranging from
10(-19) to 10(-16) W/cm(2). The measurement of biophoton emission off
ers the attractive possibility of noninvasive monitoring of the underl
ying physiological function of a living system. In the present study,
ultraweak biophoton emission from mice with transplanted bladder cance
r was detected by a two-dimensional photon-counting system, Photon cou
nts were observed to be 1.51-4.73 times higher from the regions of unt
reated tumor than from normal regions, Our study suggests that this no
vel technique may be applicable to the diagnosis of superficial tumors
.