Two independent cross-over studies have now been carried out to evalua
te the effect of a regime of chewing sucrose-containing gum on enamel
lesion remineralization. The first study has been reported in detail e
lsewhere. This further study aimed to increase the data set with an ad
ditional 13 volunteers. Similar protocols were followed in both studie
s. Weighted averages from the two studies showed Delta z values corres
ponding to 16.8% remineralization for the gum versus 11.6% remineraliz
ation for the control (p = 0.046, two-sided). A significant difference
between test and control was evident for lesion body (p = 0.0004, two
-sided) but not for surface zone (p = 0.32, two-sided).