SURFACE MODIFICATION OF NANOPARTICLES TO OPPOSE UPTAKE BY THE MONONUCLEAR PHAGOCYTE SYSTEM

An overview of recent advances in the surface modification of colloida l particles to oppose uptake by the mononuclear phagocyte system (MPS) is presented. First, we describe the colloidal particles and hydrophi lic coating materials investigated, with particular focus on the liter ature concerning particles other than liposomes. Then the pharmacokine tics and biodistribution of these MPS-opposing systems are summarized. Finally, the mechanism behind the MPS-avoidance phenomenon is discuss ed in the light of the concept of steric stabilization, We conclude th at the literature reviewed provides enough promise for anticipating th erapeutic and diagnostic applications of surface-modified nanoparticle s.