Ae. Hawley et al., TARGETING OF COLLOIDS TO LYMPH-NODES - INFLUENCE OF LYMPHATIC PHYSIOLOGY AND COLLOIDAL CHARACTERISTICS, Advanced drug delivery reviews, 17(1), 1995, pp. 129-148
The lymphatic uptake of colloids, whether lipid or non-lipid in nature
, is determined by the physiology of the lymphatic system, and the phy
sicochemical characteristics of the colloid in question, The fate of t
he colloid is also determined by the route of administration, with the
subcutaneous route generally considered to be most appropriate for ta
rgeting to the regional lymph nodes. With greater understanding of the
se factors, it will be possible to target the lymph nodes more effecti
vely.