CHARACTERISTICS OF PARKINSONISM INDUCED B Y MPTP AND STIMULATION OF CAUDATE NUCLEI CHOLINERGIC NEURONS

An experimental parkinsonian syndrome (PS) was induced by systemic adm inistration of MPTP or oxotremorine, by intranigral administration of MPP+ or injection of acetyl choline and proserine into the rostral par t of both caudate nuclei. The development of extrapyramidal-disorders was studied simultaneously with EEG-recording. The electric activity ( EA) was recorded in the sensorimotor cortex, caudate nuclei, ventrolat eral nuclei of the thalami, substantia nigra and globus pallidus. Trem or, oligokinesia and rigidity were characterized by the appearance of paroxismal activity on EA with high amplitude of slow and rapid waves. The data obtained allow us to conclude that PS neuropathophysiologica l basis is the formation of the generator of pathologically enhanced e xcitation (GPEE) in the caudate nuclei. It was found that akinesia-rig idity syndromes were observed in the rats with both MPTP and MPP+-indu ced PS. Tremor was observed after administration of oxotremorine or ac etyl choline with proserine more often than after treatment with MPTP or MPP+. Some peculiarities of the GPEE activity in these forms of PS were observed. Also, there is dissociation in effects of antiparkinson ian drugs in different forms of PS.