DOPAMINE ANTIBODIES IN PARKINSONIAN-PATIE NTS AND THEIR POSSIBLE ROLEIN THE PARKINSONS SYNDROME PATHOGENESIS

Dopamine antibodies (DAb) were found in the blood serum of parkinsonia n patients, middle-aged and elderly, but not young. There was a correl ation between the DAb incidence and dominant symptom in the middle-age d and elderly patients and between DAb and anginal parkinsonism in the elderly patients. DAb-binding serum gamma-globulins of parkinsonian p atients injected into rat caudate nuclei induced the pathogenetic mech anism of Parkinson's syndrome (the generator of pathologically enhance d excitation-GPEE) in this brain part and evoked main parkinsonian sym ptoms (oligokinesia, rigidity and tremor). This effect was more expres sed in the elderly rats compared with the young animals. The DAb role in the Parkinson's syndrome pathogenesis and in L-DOPA therapeutic tol erance formation is discussed.