This study was done on 5 patients suffering from tropical sprue (8-10
years' duration). Serum vitamin E level was significantly low in these
patients. Cell-mediated immune mechanism assessed by using 2,4-dinitr
ochlorobenzene, a skin-sensitizing hapten, was also depressed. Polyneu
ropathy was also observed. Repletion of vitamin deficiency was associa
ted with marked improvement in T-cell functions and neuropathy.