THIOPENTONE PRETREATMENT FOR PROPOFOL INJECTION PAIN IN AMBULATORY PATIENTS

Citation
Rd. Haugen et al., THIOPENTONE PRETREATMENT FOR PROPOFOL INJECTION PAIN IN AMBULATORY PATIENTS, Canadian journal of anaesthesia, 42(12), 1995, pp. 1108-1112
Citations number
17
Categorie Soggetti
Anesthesiology
ISSN journal
0832610X
Volume
42
Issue
12
Year of publication
1995
Pages
1108 - 1112
Database
ISI
SICI code
0832-610X(1995)42:12<1108:TPFPIP>2.0.ZU;2-D
Abstract
This study investigated propofol injection pain in patients undergoing ambulatory anaesthesia. In a randomized, double-blind trial, 90 women were allocated to receive one of three treatments prior to induction of anaesthesia with propofol. Patients in Group C received 2 ml normal saline, Group L, 2 ml lidocaine 2% (40 mg) and Group T, 2 ml thiopent one 2.5% (50 mg). Venous discomfort was assessed with a visual analogu e scale (VAS) 5-15 sec after commencing propofol adminitration using a n infusion pump (rate 1000 mu g . kg(-1). min(-1)). Loss of consciousn ess occurred in 60-90 sec. Visual analogue scores (mean +/- SD) during induction were lower in Groups L (3.3 +/- 2.5) and T (4.1 +/- 2.7) th an in Group C (5.6 +/- 2.3); P = 0.0031. The incidence of venous disco mfort was lower in Group L (76.6%; P < 0.05) than in Group C (100%) bu t not different from Group T (90%). The VAS scores for recall of pain in the recovery room were correlated with the VAS scores during induct ion (r = 0.7045; P < 0.0001). Recovery room discharge times were simil ac C (75.9 +/- 19.4 min); L 73.6 +/- 21.6 min); T (77.1 +/- 18.9 min). Assessing their overall satisfaction, 89.7% would choose propofol ana esthesia again. We conclude that lidocaine reduces the incidence and s everity of propofol injection pain in ambulatory patients whereas thio pentone only reduces its severity.