THIOPENTONE PRETREATMENT FOR PROPOFOL INJECTION PAIN IN AMBULATORY PATIENTS

This study investigated propofol injection pain in patients undergoing ambulatory anaesthesia. In a randomized, double-blind trial, 90 women were allocated to receive one of three treatments prior to induction of anaesthesia with propofol. Patients in Group C received 2 ml normal saline, Group L, 2 ml lidocaine 2% (40 mg) and Group T, 2 ml thiopent one 2.5% (50 mg). Venous discomfort was assessed with a visual analogu e scale (VAS) 5-15 sec after commencing propofol adminitration using a n infusion pump (rate 1000 mu g . kg(-1). min(-1)). Loss of consciousn ess occurred in 60-90 sec. Visual analogue scores (mean +/- SD) during induction were lower in Groups L (3.3 +/- 2.5) and T (4.1 +/- 2.7) th an in Group C (5.6 +/- 2.3); P = 0.0031. The incidence of venous disco mfort was lower in Group L (76.6%; P < 0.05) than in Group C (100%) bu t not different from Group T (90%). The VAS scores for recall of pain in the recovery room were correlated with the VAS scores during induct ion (r = 0.7045; P < 0.0001). Recovery room discharge times were simil ac C (75.9 +/- 19.4 min); L 73.6 +/- 21.6 min); T (77.1 +/- 18.9 min). Assessing their overall satisfaction, 89.7% would choose propofol ana esthesia again. We conclude that lidocaine reduces the incidence and s everity of propofol injection pain in ambulatory patients whereas thio pentone only reduces its severity.