SELECTIVE N-FUNCTIONALIZATION OF 6-SUBSTITUTED-2-PYRIDONES

Authors
LIU H KO SB JOSIEN H CURRAN DP
Citation
H. Liu et al., SELECTIVE N-FUNCTIONALIZATION OF 6-SUBSTITUTED-2-PYRIDONES, Tetrahedron letters, 36(49), 1995, pp. 8917-8920
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
49
Year of publication
1995
Pages
8917 - 8920
Database
ISI
SICI code
0040-4039(1995)36:49<8917:SNO6>2.0.ZU;2-8
Abstract
6-Substituted-2-pyridones can be selectively N-alkylated by treatment with NaH/LiBr in a mixture of DMF and DME. Yields of N-propargylated, N-allylated, and other N-functionalized products are good, and only sm all amounts of the isomeric O-alkylated product (<10%) are typically f ormed.