METHYLAMINE DEPROTECTION PROVIDES INCREASED YIELD OF OLIGORIBONUCLEOTIDES

Authors
REDDY MP FAROOQUI F HANNA NB
Citation
Mp. Reddy et al., METHYLAMINE DEPROTECTION PROVIDES INCREASED YIELD OF OLIGORIBONUCLEOTIDES, Tetrahedron letters, 36(49), 1995, pp. 8929-8932
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
49
Year of publication
1995
Pages
8929 - 8932
Database
ISI
SICI code
0040-4039(1995)36:49<8929:MDPIYO>2.0.ZU;2-7
Abstract
Use of methylamine or methylamine/ammonium hydroxide as a cleavage and deprotection reagent for the solid phase synthesis of oligoribonucleo tides has significantly increased the yield of the full length oligori bonucleotides as compared to the use of conventional ammonium hydroxid e/ethanol.