A CHEMOENZYMATIC SYNTHESIS OF A-RING KEY-INTERMEDIATES FOR 1-ALPHA,25-DIHYDROXYVITAMIN D-3 AND ANALOGS

Authors
VRIELYNCK S VANDEWALLE M GARCIA AM MASCARENAS JL MOURINO A
Citation
S. Vrielynck et al., A CHEMOENZYMATIC SYNTHESIS OF A-RING KEY-INTERMEDIATES FOR 1-ALPHA,25-DIHYDROXYVITAMIN D-3 AND ANALOGS, Tetrahedron letters, 36(49), 1995, pp. 9023-9026
Citations number
39
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
49
Year of publication
1995
Pages
9023 - 9026
Database
ISI
SICI code
0040-4039(1995)36:49<9023:ACSOAK>2.0.ZU;2-C
Abstract
A short and practical synthesis of the 1,7-enyne A-ring intermediate a nd of Uskokovic's phosphine-oxide precursor is described starting from the aldol product of acrolein with t-butyl acetate. Enantiopure beta- hydroxy ester is obtained upon lipase-catalyzed resolution.