CYCLOSPORINE-INDUCED REMISSION IN AM INFANT WITH ALKYLATING AGENTS-RESISTANT NEPHROTIC SYNDROME - A CASE-REPORT

The efficacy of cyclosporin-A, a potent immunosuppressive agent, has n ot been clearly proven in the management of childhood nephrotic syndro me. The occurrence of early relapse as the dose of cyclosporin is tape red or as soon as the drug is stopped and the potential nephrotoxic ef fects of prolonged treatment have caused it to be used in limited case s. We report an eighteen-month-old boy with steroid toxicity and alkyl ating agents-resistant nephrotic syndrome, who subsequently went very quickly into remission lasting at least one year after receiving cyclo sporin-A for only three months.