Tr. Juneja et al., MUTAGENICITY OF NITROBENZYL DERIVATIVES - POTENTIAL BIOREDUCTIVE ANTICANCER AGENTS, Mutation research. Mutation research letters, 348(3), 1995, pp. 137-145
Ortho-, meta- and para-nitrobenzyl bromides, alcohols, ethers and este
rs were synthesised and tested for their mutagenicity toward Salmonell
a typhimurium TA100, TA100NR (nitroreductase deficient) and TA98 in ab
sence of S9 mix and in TA100 with S9 mix. Compounds of the ortho- and
meta-series were non mutagenic with and without S9 mix. Except for the
alcohol and ether, the compounds of the pam-series were mutagenic in
TA100 with activity sequence propionate > butyrate > benzoate > acetat
e > bromide and this specific activity was reduced considerably by S9
mix. The Ames Salmonella test system does not seem to be an appropriat
e model to evaluate mutagenicity of o-nitrobenzyls. However, further w
ork is in progress to test all the compounds fbr mutagenicity in mamma
lian system.