PREECLAMPSIA DOES NOT ALTER THE RESPONSE TO ENDOTHELIN-1 IN HUMAN OMENTAL ARTERY

Citation
Yp. Vedernikov et al., PREECLAMPSIA DOES NOT ALTER THE RESPONSE TO ENDOTHELIN-1 IN HUMAN OMENTAL ARTERY, Journal of cardiovascular pharmacology, 26, 1995, pp. 233-235
Citations number
10
Categorie Soggetti
Cardiac & Cardiovascular System","Respiratory System","Pharmacology & Pharmacy
ISSN journal
01602446
Volume
26
Year of publication
1995
Supplement
3
Pages
233 - 235
Database
ISI
SICI code
0160-2446(1995)26:<233:PDNATR>2.0.ZU;2-1
Abstract
Endothelin-1 (ET-1), known to be present in high concentrations in ser um from pre-eclamptic compared with normotensive pregnant women, may c ontribute to the increased vascular reactivity seen in preeclampsia. E xperiments were designed to compare the contractile activity of ET-1 i n isolated omental arteries from menopausal women (n = 6), normotensiv e pregnant women (n = 7), and pre-eclamptic patients (n = 7). Intact r ings (3-mm width) were suspended for isometric tension recording in or gan chambers filled with modified Krebs/bicarbonate buffer aerated wit h 95% air and 5% CO2, 37 degrees C, pH 7.35-7.4, under tension of 1 g. No significant differences were found in either the sensitivity to (c oncentration producing 50% of contraction) or efficacy of (maximal inc rease in tension, normalized to reference contraction to KCl) ET-1 in the vessels of all three groups of patients studied. These data argue against ET-1 as a primary factor in pre-eclampsia. The modulatory role of ET-1 on the effects of other contractile factors of human blood, a s a possible cause of pre-eclamptic changes, remains to be elucidated.