CHARACTERISTICS OF THE THERMAL-DECOMPOSITION OF ANTITUBERCULOUS DRUGS

Authors
WESOLOWSKI M KONARSKI T
Citation
M. Wesolowski et T. Konarski, CHARACTERISTICS OF THE THERMAL-DECOMPOSITION OF ANTITUBERCULOUS DRUGS, Journal of thermal analysis, 45(5), 1995, pp. 1199-1204
Citations number
18
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of thermal analysis → ACNP
ISSN journal
03684466
Volume
45
Issue
5
Year of publication
1995
Pages
1199 - 1204
Database
ISI
SICI code
0368-4466(1995)45:5<1199:COTTOA>2.0.ZU;2-T
Abstract
The thermal decomposition of antituberculous drugs-ethambutol (base an d dihydrochloride), isoniazid, ethionamid and pyrazinamid has been stu died by DTA, TG and DTG techniques. General remarks have been made on their thermal destruction. The effect of sample size over the range 20 -200 mg and heating rate over the range 3-15 deg . min(-1) on the ther mal degradation has also been investigated. Moreover, based on the Kis singer's equation, the values of the kinetic parameters were determine d.