A 30-year-old female with chronic hepatitis C treated with recombinant
alpha-interferon developed serious hemolytic anemia after receiving 1
0 million units a day for 4 weeks. The results of Coombs' tests were n
egative before and after interferon therapy. The hemolytic anemia grad
ually improved after the withdrawal of recombinant alpha-interferon an
d the administration of methyl-prednisolone. The clinical course sugge
sted that the recombinant alpha-interferon had provoked the hemolytic
anemia.