Objective: To examine the accuracy of previously published formulas to
estimate fetal weight (EFW) in second trimester fetuses and to derive
new formulas to EFW in the second trimester. Methods: Obstetrical rec
ords and sonograms were reviewed for 68 fetuses born between 14 and 24
weeks with known actual birthweight, no congenital anomalies, and bio
metric data within 4 days of birth. Six previously published formulas
using a combination of two or more biometric parameters were examined,
Birthweight predictive accuracy was evaluated by mean residual, stand
ard error (SE) residual, mean absolute residual, SE absolute residual,
the mean deviation of the signed percent error, mean absolute percent
error, mean deviation, standard deviation, and EFW prediction within
5, 10, and 20%. New formulas to EFW were derived by stepwise regressio
n analysis. Results: A previously published formula using abdominal ci
rcumference (AC) and femur length (FL) was better than the biparietal
diameter (BPD) and AC formula in all. respects and better or comparabl
e to formulas using three or more parameters. Three new formulas were
derived using head circumference (HC) and FL to obtain the best predic
ted birthweight. Conclusion: For estimation of fetal weight in second
trimester fetuses, one of the previously published formulas using AC a
nd FL was reasonably accurate, The new HC and FL formula's accuracy sh
ould be studied prospectively. Second trimester EFW curves may be usef
ul to identify fetuses at risk for impaired growth.