Background. Risk behavior contributes to injuries, one of the most imp
ortant sources of morbidity and mortality in adolescents. Although res
earch has shown that environmental stress makes adolescents more likel
y to engage in risk behavior and to sustain injuries, the magnitude of
these associations has been small. Little is known about the role of
individual differences in psychobiologic reactivity to stress in moder
ating the impact of stressful events. In this study, we examined assoc
iations among environmental stressors, cardiovascular reactivity to st
ress, and the level of risk behavior in adolescent boys. Methods. Twen
ty-four 14- to 16-year-old boys underwent a laboratory protocol design
ed to measure responses to psychologically and physically stressful ta
sks. Changes in heart rate and mean arterial blood pressure were measu
red serially at standard points in the protocol, and levels of positiv
e and negative life events and recent risk behavior were measured usin
g self-report questionnaires. Results. Neither life events nor cardiov
ascular reactivity were independently associated with risk behavior. P
ositive life events and mean arterial blood pressure reactivity signif
icantly interacted, however, in predicting risk behavior (R(2) increme
nt = .25). Boys with high reactivity who reported numerous positive li
fe events engaged in markedly less risk behavior than their peers. Con
clusion. We conclude that adolescents with exaggerated cardiovascular
responses to laboratory stressors are associated with less risk behavi
or in a setting of positive life circumstances. This result suggests t
hat reactivity may exert protective, rather than harmful, influences i
n some environments.