We have used a local World Wide Web (WWW) server to organize protein a
nd DNA sequences that are used frequently in our laboratory. WWW serve
r programs are available for most computer platforms and are easily se
t up with minimal computer skills. This approach allows for the easy r
etrieval of sequence data, which can then be used as input for other a
nalysis programs. This format is especially simple to use in conjuncti
on with WWW database searches. The sequence files may be served to the
''public'' Internet or kept private by requiring a password for acces
s. Other advantages are (i) sequences can be accessed from multiple co
mputer platforms using the appropriate WWW-browser; (ii) files can be
accessed remotely from any computer on the Internet; (iii) only a sing
le sequence format is used, simplifying the updating and archiving of
data; and (iv) links to remote files can also be served in addition to
local files.