FUNCTION OF THE RAT SALIVARY-GLANDS AFTER EXPOSURE TO INORGANIC MERCURY

In spite of many studies on the toxicity of mercury, very little is kn own about the effects of mercury on the function of exocrine glands. I n the present paper selected functions of Sprague-Dawley rat salivary glands were studied after the exposure of the animals to inorganic mer cury at two different doses; 3.25 mg/kg body weight given during 25 da ys and 7.0 mg/kg body weight given during 27 days. The function of the salivary glands was estimated by saliva secretion rate, secretion of electrolytes, proteins and biosynthesis of glycoproteins. The function was compared between mercury exposed rats and age and sex matched con trol rats that were given injections with equal volumes of 0.154 mol/l NaCl on the same time schedule. In the present study we report that n o significant effect on saliva secretion rate, concentrations of saliv ary constituents or biosynthesis of glycoproteins in the salivary glan ds could be observed in rats as a result of mercury exposure at two le vels that gave 30 or 60 times higher serum mercury concentrations than in the majority of the Swedish population.