ANALYTICAL AND RADIOANALYTICAL QUALITY-CONTROL IN HIGH SPECIFIC ACTIVITY RADIOTRACER PREPARATION

High specific activity radiotracers, used in studies related to trace elements and human health, must be characterized by the following spec ific requirements: (i) high specific activity (activity/mass of isotop ic carrier), (ii) high activity concentration (activity/volume or mass of substrate), (iii) radionuclidic, radiochemical and chemical puriti es, (iv) biological compatibility (physiological pH, sterility and phy siological values). For this purpose, selective radiochemical separati ons and quality control procedures have been developed and tested at o ur laboratories for the production of several NCA radiotracers.