To assess the influence on the risk of hip fractures in men of medical
conditions associated,with secondary osteoporosis or with an increase
d likelihood of falling, we conducted a population-based nested case-c
ontrol study among the 232 Rochester, Minnesota, men with an initial h
ip fracture due to moderate trauma in 1965-1989 and an equal number of
age-matched control men from the general population, Information on s
elected medical and surgical conditions and certain behavioral risk fa
ctors prior to fracture (or comparable index date for controls) was ob
tained from inpatient and outpatient medical records in the community
that averaged over 36 years in duration. After adjusting for age, obes
ity, and inactivity, disorders linked with secondary osteoporosis were
associated with a 2-fold increase in the risk of hip fracture in men
(odds ratio [OR] 2.3; 95% confidence interval [CI] 1.3-4.3), while con
ditions linked with an increased risk of falling were associated with
almost a 7-fold increase in risk (OR 6.9; 95% CI 3.3-14.8). These fact
ors together appeared to account for about 72% of the hip fractures in
men, Increased attention must be paid to these conditions which, in a
ggregate, are very common in elderly men and lead to a substantial inc
rease in the risk of hip fracture with its devastating sequelae of dea
th, disability, and cost.