Although bone scintigraphy is an extremely sensitive method for the de
tection of focal bone disease, small lesions below the resolution of p
lanar imaging may be missed. This is a report of a patient with carcin
oma of the breast who showed tumor progression 1 year after initial tr
eatment. Complete evaluation was performed in order to detect the orig
in of increased level of a tumor marker, Although planar bone scintigr
aphy could not demonstrate any lesion in the spine, multiple metastase
s were detected in the lumbar and the thoracic spines on SPECT imaging
. Only some of these lesions were seen with MRI. Repeat planar bone im
aging 6 weeks later showed multiple bone lesions in the lumbar and tho
racic areas.