SYNTHESIS AND PHARMACOLOGICAL EVALUTATION OF THIENO[2,3-D] PYRIMIDIN-2,4-DIONE AND 5H-PYRIMIDO [5,4-B]INDOL-2,4-DIONE DERIVATIVES

Two series of novel derivatives based on the thienopyrimidine and pyri midoindole ring systems, both N-substituted in position 3, have been s ynthesized. The compounds were obtained by reaction of N-amino groups of 5,6-dimethyl-thieno[2,3-d]pyrimidin-2,4-dione and of 5H-pyrimido[5, 4-b]indol-2,4-dione with aromatic aldehydes. Some of these substances showed an appreciable analgesic activity, a good antiinflammatory acti tivity, a low acute toxicity with an optimal gastric tolerance.