A LARGE MULTISITE CANCER FAMILY IS LINKED TO BRCA2

Authors
TONIN P GHADIRIAN P PHELAN C LENOIR GM LYNCH HT LETENDRE F BELANGER D MONTE M NAROD SA
Citation
P. Tonin et al., A LARGE MULTISITE CANCER FAMILY IS LINKED TO BRCA2, Journal of Medical Genetics, 32(12), 1995, pp. 982-984
Citations number
7
Categorie Soggetti
Genetics & Heredity
Journal title
Journal of Medical Genetics → ACNP
ISSN journal
00222593
Volume
32
Issue
12
Year of publication
1995
Pages
982 - 984
Database
ISI
SICI code
0022-2593(1995)32:12<982:ALMCFI>2.0.ZU;2-P
Abstract
We identified a large French-Canadian family with 21 cases of breast c ancer, including two affected brothers. Segregation of markers from ch romosome 13q in this family showed linkage to the BRCA2 gene locus (lo d=3.67 at D13S289). A number of cancers of other types occurred in thi s family, including three cases of prostate cancer and two cases of ly mphoma. The penetrance of breast cancer among BRCA2 carriers is estima ted to be 75% to the age of 70.