BIOARTIFICIAL MATERIALS BASED ON COLLAGEN .1. COLLAGEN CROSS-LINKING WITH GASEOUS GLUTARALDEHYDE

Authors
BARBANI N GIUSTI P LAZZERI L POLACCO G PIZZIRANI G
Citation
N. Barbani et al., BIOARTIFICIAL MATERIALS BASED ON COLLAGEN .1. COLLAGEN CROSS-LINKING WITH GASEOUS GLUTARALDEHYDE, Journal of biomaterials science. Polymer ed., 7(6), 1995, pp. 461-469
Citations number
17
Categorie Soggetti
Engineering, Biomedical","Polymer Sciences","Materials Science, Biomaterials
Journal title
Journal of biomaterials science. Polymer ed. → ACNP
ISSN journal
09205063
Volume
7
Issue
6
Year of publication
1995
Pages
461 - 469
Database
ISI
SICI code
0920-5063(1995)7:6<461:BMBOC.>2.0.ZU;2-5
Abstract
The effect of exposure time of thin films of soluble collagen to gluta raldehyde (GTA) vapour was studied at 37 degrees C, and was evaluated by examining the thermal and biological stability and the swelling rat io. It was found that the collagen films treated with GTA vapour for 1 8 h showed the highest denaturation temperature, the lowest swelling r atio, and an enhanced proteolytic stability. This study shows that sol uble collagen can be effectively cross-linked with GTA vapour and that the degree of cross-linking can be controlled by varying the exposure time.