Sd. Lennox et al., INFLUENCE OF ORTHOSTATIC HYPOTENSION IN PARKINSONS-DISEASE ON PLASMA ATRIAL-NATRIURETIC-PEPTIDE, Archives of gerontology and geriatrics, 21(3), 1995, pp. 317-320
The effect of orthostatic hypotension in Parkinson's disease (PD) on p
lasma atrial natriuretic peptide (ANP) was examined in fifteen individ
uals with PD without autonomic dysfunction (63-85 years), nine PD pati
ents with autonomic dysfunction (orthostatic hypotension; systolic BP
change > 20 mmHg after 5 min standing: 69-82 years) and 14 fit elderly
volunteers (62-93 years). The mean ANP level was 42.2 pg/ml (range 16
.8-89.2 pg/ml) in the PD group without autonomic dysfunction; 44.4 pg/
ml (range 27.2-91.2 pg/ml) in the PD group with autonomic dysfunction;
and 48.5 pg/ml (range 22.2-111.6 pg/ml) in the elderly group. There w
as no statistical difference in plasma atrial natriuretic peptide betw
een all three groups. The mean change in blood pressure was -39 mmHg (
systolic) and -18 mmHg (diastolic) between supine and standing in the
group with orthostatic hypotension.