INTRAVENOUS ADMINISTRATION OF CHOLECYSTOKININ (CCK) STIMULATES PROLACTIN AND GROWTH-HORMONE RELEASE IN THE PIG

Authors
PARROTT RF EBENEZER IS BALDWIN BA BUTTLE HL
Citation
Rf. Parrott et al., INTRAVENOUS ADMINISTRATION OF CHOLECYSTOKININ (CCK) STIMULATES PROLACTIN AND GROWTH-HORMONE RELEASE IN THE PIG, Methods and findings in experimental and clinical pharmacology, 17(8), 1995, pp. 529-533
Citations number
29
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Methods and findings in experimental and clinical pharmacology → ACNP
ISSN journal
03790355
Volume
17
Issue
8
Year of publication
1995
Pages
529 - 533
Database
ISI
SICI code
0379-0355(1995)17:8<529:IAOC(S>2.0.ZU;2-E
Abstract
Blood samples were taken from prepubertal pigs (n = 7) surgically prep ared with venous catheters before, and at intervals during the 30 min period after, administration of physiological saline (vehicle) or sulp hated cholecystokinin octapeptide (CCK) (0.3, 0.7 and 1.3 mu g/kg). Pl asma concentrations of prolactin and growth hormone were measured by r adioimmunoassay. Statistically significant dose-related increases in p rolactin occurred mainly in the first 10-min period following CCK admi nistration. The peptide also stimulated growth hormone secretion altho ugh in a less consistent manner, with the increases tending to occur o ver a longer time period.