In the brain of aged rats high affinity choline uptake (HAChU) of the
striatum, hippocampus, and frontal cortex is lower than in young rats,
while choline acetyltransferase (ChAT) activity is lower in striatum
and frontal cortex. Infusion into the lateral cerebral ventricle with
nerve growth factor (NGF) enhances the low values of these cholinergic
markers in a dose- and region-dependent manner. GM1 ganglioside infus
ed into the lateral ventricle, at a dose that is ineffective alone, to
gether with NGF synergistically enhances the effect of NGF on ChAT and
HAChU activities in the brain of aged animals. The pharmacology of th
is GM1/NGF synergism suggests potentiation of response.