NEW CHEMICALLY BONDED CHIRAL LIGAND-EXCHANGE CHROMATOGRAPHIC STATIONARY PHASES

The development of two new chemically bonded chiral ligand-exchange ch romatographic phases is described. These phases were prepared by bindi ng L-proline to silica gel via different spacer groups. The influence of the structure of the spacer on the enantioselectivity was studied. These phases showed enantioselectivity of enantiomer separation for ma ny classes df substance that form chelate complexes, such as amino aci ds, dansylamino acids, dipeptides, hydroxy acids and barbiturates.