ENANTIOSELECTIVE SEPARATIONS BY CAPILLARY GAS-CHROMATOGRAPHY ON DERIVATIZED CYCLODEXTRINS .3. SEPARATION OF SOME RACEMIC 2,2-DIALKYL-4-ALKOXYCARBONYL-1,3-DIOXOLANE DERIVATIVES ON ETYL-6-O-TERT-BUTYLDIMETHYLSILYL-BETA-CYCLODEXTRIN AND TYL-6-O-TERT-BUTYLDIMETHYLSILYL-GAMMA-CYCLODEXTRIN

The enantioseparation of a set of 2,2-dialkyl-4-alkoxycarbonyl-1,3-dio xolane derivatives, which are important intermediates in the total syn thesis of biologically active compounds, was studied by means of capil lary gas chromatography (cGC). The chromatographic results, obtained o n columns coated with 2,3-di-O-acetyl-6-O-tert. -butyldimethylsilyl-be ta- and -gamma-cyclodextrins are reported. Most of the compounds could be separated with a resolution greater than 1.42. Considerations conc erning the interaction mechanism are presented.