CHIRAL SEPARATIONS PERFORMED BY SUPERCRITICAL-FLUID CHROMATOGRAPHY

Supercritical fluid chromatography is an attractive alternative for ch iral separations of compounds which are not readily analyzed by gas ch romatography. It offers fast separations, high-efficiency, low-tempera ture analysis and access to a wide range of detectors including the '' universal'' flame ionization detector. In this article the state of th e art is reviewed. The technique is compared with other chromatographi c techniques and the applicability of different chiral stationary phas es as well as the choice of experimental conditions is discussed.