ANALYSIS OF THE CONTRAST AGENT IOPAMIDOL IN SERUM BY CAPILLARY ELECTROPHORESIS

A rapid method for the analysis of the contrast agent iopamidol (isovu e) in serum by CE is described. The method involves deproteinzation wi th acetonitrile to remove serum proteins followed by direct capillary zone electrophoresis. It is rapid (about 10 min) and sensitive. Other contrast agents and compounds used for renal function tests such as io hexol, iothalamic acid and p-aminohippuric acid can be detected by the same method. The use of acetonitrile in this method to remove serum p roteins results in sample stacking allowing the detection of levels le ss than 1 mg/L.