OBJECTIVE: To examine the effect of a moderate exercise regimen on tot
al serum cholesterol, triglyceride, high density lipoprotein cholester
ol (HDL-C), low density lipoprotein cholesterol (LDL-C), body composit
ion and cardiovascular fitness (VO2 max) in mildly hyperlipidemic wome
n, postmenopause. DESIGN: Randomized assignment to walking (n=24) or c
ontrol (n=16) groups. SETTING: Community based intervention. PARTICIPA
NTS: Over 300 volunteers were screened to obtain the sample of 40 elig
ible women. Participants were mildly hyperlipidemic, postmenopause (me
an age 62.0+/-5.7 years), sedentary, nonsmokers and not on hormone rep
lacement therapy. Results are reported for the 25 subjects (15 walkers
, 10 controls) who completed the study. INTERVENTION: Exercisers walke
d an average of 54.3+/-7.7 mins/day, 4.9+/-1.7 days/week, at an intens
ity of 54% maximum heart rate reserve, for six months. Participants we
re counselled not to change their diets. MAIN RESULTS: Total serum cho
lesterol, triglyceride total serum cholesterol: HDL-C ratio, weight an
d fat mass decreased significantly in the walkers compared with the co
ntrols (P<0.05), as did body mass index (P<0.01). Walking resulted in
a significant increase in VO2 max (P<0.01). changes in serum lipids we
re significantly related to changes in body fat, but not to change in
aerobic fitness. There were no changes in dietary intake. CONCLUSIONS:
A moderate intensity exercise program induces favourable alterations
in total serum cholesterol and other atherogenic indices in hyper-lipi
demic women postmenopause, and these changes are related more to loss
of body fat than to increased fitness level.