LOCALIZATION OF ANGIOTENSIN-IV BINDING-SITES TO MOTOR AND SENSORY NEURONS IN THE SHEEP SPINAL-CORD AND HINDBRAIN

In the sheep spinal cord, a high density of [I-125]angiotensin IV bind ing sites was localized to the perikaryon and processes of all somatic motor neurons, the autonomic motor neurons in the lateral hems of tho racic and lumbar segments and all dorsal root ganglia, but was low in lamina II of all dorsal horns. At supraspinal levels, [I-125]angiotens in IV binding was abundant in numerous motor associated regions, with weaker binding observed in the sensory regions. This wide distribution pattern suggests an important role for the binding site in the centra l nervous system.