A NEW HIGH-YIELD SEMISYNTHETIC APPROACH TO (20S)-9-NH2-CAMPTOTHECIN BASED ON A SEQUENCE OF PALLADIUM-CATALYZED REDUCTIONS

Authors
CABRI W CANDIANI I ZARINI F PENCO S BEDESCHI A
Citation
W. Cabri et al., A NEW HIGH-YIELD SEMISYNTHETIC APPROACH TO (20S)-9-NH2-CAMPTOTHECIN BASED ON A SEQUENCE OF PALLADIUM-CATALYZED REDUCTIONS, Tetrahedron letters, 36(50), 1995, pp. 9197-9200
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
50
Year of publication
1995
Pages
9197 - 9200
Database
ISI
SICI code
0040-4039(1995)36:50<9197:ANHSAT>2.0.ZU;2-P
Abstract
A new 5-step synthesis of 9-NH2-Camptothecin starting from naturalCamp tothecin is described. The approach, centred on a double palladium cat alysed reduction of an arylsulfonate and a nitro group, has an overall yield consistently higher than the previously reported ones.