The synthesis of different anthracyclines of the daunorubicin family,
fluorinated at position 8 or 10 is described. The 8-fluoroderivatives
(2a-c) were obtained by glycosylation of the corresponding fluorinated
aglycones. The 10-fluoroderivatives (2d-g) were synthesized directly
from daunorubicin (1a) and idarubicin (1c) following a non deglycosida
tive approach. 8-(S)-Fluorodoxorubicin was obtained from 8-(S)-fluorod
aunorubicin, although in very low yield.