DIFLUOROMETHYLENEKETONE RETROAMIDE, A VERSATILE CONCEPT OF INACTIVATION OF PROTEOLYTIC-ENZYMES

Authors
SCHIRLIN D BALTZER S ALTENBURGER JM TARNUS C REMY JM
Citation
D. Schirlin et al., DIFLUOROMETHYLENEKETONE RETROAMIDE, A VERSATILE CONCEPT OF INACTIVATION OF PROTEOLYTIC-ENZYMES, Tetrahedron, 52(1), 1996, pp. 305-318
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
52
Issue
1
Year of publication
1996
Pages
305 - 318
Database
ISI
SICI code
0040-4020(1996)52:1<305:DRAVCO>2.0.ZU;2-E
Abstract
The synthesis of difluoromethyleneketone retroamides is described. Sev eral examples of application to aspartyl or seryl proteases illustrate the versatility of this inactivation concept.