P53 EXPRESSION IN BREAST-CANCER RELATED TO PROGNOSTIC FACTORS

In this article the results of molecular marker p53 examinations were presented in relation to the following established breast cancer progn ostic factors: age, histologic type, histologic grade, lymph node invo lvement, tumor size as well as estrogen a progesterone receptor status . Twenty one percent of these primary breast cancer specimens exhibite d the overexpression of p53 protein. Significant associations were fou nd between p53 overexpression and younger age, high histologic grade a nd low content of estrogen and progesterone receptors. Identification of p53-positive breast carcinomas potentially represents a clinically useful indicator of breast cancer aggressiveness.