RADIOEMBOLISATION OF HEPATOCELLULAR-CARCINOMA WITH 90-YTTRIUM RESIN PARTICLES

In 19 patients (34 applications) radioembolisation with Y-90 resin par ticles applied superselectively with microcatheters was carried out as a palliative treatment of liver cell carcinoma. The calculations of t umour doses and of exposure to the liver parenchyma and lung were made following angioscintigraphy with Tc-99m-MAP. In 27 patients the tumou r dose was between 50 and 470 Gy, in 5 patients <50 Gy and in 2 patien ts >800 Gy. The adjacent liver parenchyma was exposed to 13% of the ta rgeted tumour dose (mean 34 Gy). The lung shunt in 31 applications was between 0 and 8%, in three instances between 12 and 14%. Complication s due to shunt or reflux were observed in 2 patients. Small solitary h ypervascularised tumours showed the most improvement (high dose/low-vo lume embolisation). In multi-segmental/lobar tumours, radioembolisatio n with smaller doses (<100 Gy) showed good palliative effects (medium dose/limited-volume embolisation).