CALLA POSITIVE ACUTE LYMPHOBLASTIC-LEUKEMIA AFTER ETOPOSIDE-BASED THERAPY FOR EWINGS-SARCOMA

This is an unusual and interesting case report concerning a 10 year ol d boy with an initial diagnosis of Ewing's sarcoma of the right tibia. He was successfully treated with a chemotherapy regimen consisting of vincristine, cyclophosphamide (cumulative dose 7200 mg/m(2)), doxorub icin, etoposide (cumulative dose 2700 mg/m(2)) and cisplatin and local radiotherapy to the tibia. After an interval of 37 months he develope d CALLA positive acute lymphoblastic leukemia with 11q23 chromosomal a bnormality. The possible roles of etoposide and cyclophosphamide are d iscussed.