BCR-ABL REARRANGEMENT AND VARIANT PHILADELPHIA-CHROMOSOME IN DE-NOVO ACUTE MYELOGENOUS LEUKEMIA FAB SUBTYPE M1

Authors
CIGUDOSA JC ALMEIDA MTA CARRASCO V BELLO T CARRASCO JL GOMEZ AO GARCIA J TALAVERA JG MIRANDA JLG
Citation
Jc. Cigudosa et al., BCR-ABL REARRANGEMENT AND VARIANT PHILADELPHIA-CHROMOSOME IN DE-NOVO ACUTE MYELOGENOUS LEUKEMIA FAB SUBTYPE M1, British Journal of Haematology, 91(4), 1995, pp. 932-934
Citations number
9
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
91
Issue
4
Year of publication
1995
Pages
932 - 934
Database
ISI
SICI code
0007-1048(1995)91:4<932:BRAVPI>2.0.ZU;2-D
Abstract
We report a case of de novo acute myelogenous leukaemia FAB subtype M1 that presents a cytogenetic complex translocation between chromosomes 7, 9 and 22, producing a 'variant' Philadelphia chromosome, Molecular analysis revealed a BCR-ABL rearrangement involving exons b3 and a2 ( b3a2). Haematological parameters and genetic analysis again raise the problem of the true nature of this disease, which is briefly discussed .