C. Klein et al., EBV-ASSOCIATED LYMPHOPROLIFERATIVE SYNDROME WITH A DISTINCT 69 BASE-PAIR DELETION IN THE LMP-1 ONCOGENE, British Journal of Haematology, 91(4), 1995, pp. 938-940
We describe an immunocompetent 12-year-old boy with chronic EBV infect
ion and lymphoid interstitial pneumonitis. Lymphnode biopsies showed e
ffacement of the architecture with polymorphic cellular infiltrates, c
onsisting predominantly of T cells and natural killer cells. No clonal
rearrangement of TCR or immunoglobulin genes was seen, DNA was extrac
ted from hilar lymph nodes; sequencing of the carboxy terminal region
of the latent membrane protein 1 (LMP-1) oncogene revealed a 69 base-p
air deletion and four point mutations. Immunosuppressive treatment wit
h prednisone and cyclosporine reversed the lymphadenopathy.