A RANDOMIZED CROSSOVER STUDY USING YOHIMBINE AND ISOXSUPRINE VERSUS PENTOXIFYLLINE IN THE MANAGEMENT OF VASCULOGENIC IMPOTENCE

Purpose: We evaluated the efficacy and safety of yohimbine and isoxsup rine or pentoxifylline in the management of vasculogenic erectile dysf unction. Materials and Methods: A total of 20 patients diagnosed with arterial insufficiency and cavernous venous leakage by pharmacological penile duplex scanning underwent nonhormonal oral therapy. A randomiz ed crossover study was performed using 5.4 mg. yohimbine plus 10 mg. i soxsuprine or 400 mg. pentoxifylline 3 times daily. Response to therap y was assessed by a sexual questionnaire and repeat penile duplex ultr asonography. Results: No patient in either phase of the study in eithe r group had a complete response to the oral regimen(s) and there was n o improvement in the pre-injection or post-injection cavernous arteria l peak systolic flow velocities or resistance indexes. Conclusions: Ou r study suggests that these oral agents, although well tolerated, were not effective in the management of these patients with mixed vasculog enic erectile dysfunction.