A NEW HUMAN GUANYLATE CYCLASE-ACTIVATING PEPTIDE (GCAP-II, UROGUANYLIN) - PRECURSOR CDNA AND COLONIC EXPRESSION

Authors
HILL O CETIN Y CIESLAK A MAGERT HJ FORSSMANN WG
Citation
O. Hill et al., A NEW HUMAN GUANYLATE CYCLASE-ACTIVATING PEPTIDE (GCAP-II, UROGUANYLIN) - PRECURSOR CDNA AND COLONIC EXPRESSION, Biochimica et biophysica acta. Protein structure and molecular enzymology, 1253(2), 1995, pp. 146-149
Citations number
24
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Protein structure and molecular enzymology → ACNP
ISSN journal
01674838
Volume
1253
Issue
2
Year of publication
1995
Pages
146 - 149
Database
ISI
SICI code
0167-4838(1995)1253:2<146:ANHGCP>2.0.ZU;2-4
Abstract
We have amplified, cloned, and sequenced 583 bp GCAP-II/uroguanylin-sp ecific cDNA from human colon cDNA first strand. The cDNA codes for a p utative 112 amino-acid precursor protein including the sequence of uro guanylin and GCAP-II. Northern blot hybridization revealed a high leve l expression of the GCAP-II gene in human colon, but not in the kidney . This expression of GCAP-II indicates a pivotal role in cGMP-mediated functions of the colon.