Tj. Mauch et al., ANTIBODY-RESPONSE OF PEDIATRIC SOLID-ORGAN TRANSPLANT RECIPIENTS TO IMMUNIZATION AGAINST INFLUENZA-VIRUS, The Journal of pediatrics, 127(6), 1995, pp. 957-960
We studied the immunogenicity of the 1992-1993 trivalent split-virus i
nfluenza vaccine in pediatric solid organ transplant recipients (PSOTR
s) and their healthy siblings, One month after immunization, 41 (82%)
of 50 subjects achieved protective titers of antibodies to influenza A
, and 30 (60%) to influenza B, rates similar to those in healthy sibli
ngs, Achievement and persistence of protective titers occurred signifi
cantly more often in children with preexisting antibody. We recommend
annual immunization of PSOTRs, their household contacts, and health ca
re workers; immunologically naive PSOTRs may benefit from immunization
before transplantation.