THE ABILITY OF CAPTOPRIL AND PERINDOPRIL TO POTENTIATE ANTIANGINAL ACTIVITY OF ISOSORBIDE DINITRATE DURING LONG-TERM USE IN PATIENTS WITH ISCHEMIC-HEART-DISEASE AND STABLE EFFORT ANGINA

Ability of ACE Inhibitors capropril (with SH-group) and perindopril (w ithout SH-group) to augment efficacy of isosorbide dinitrate was inves tigated in a randomized crossover open study in 18 patients with stabl e effort angina (9 patients had concomitant mild to moderate arterial hypertension). Captopril (50 mg) or perindopril (4 mg) were given in c ombination with isosorbide dinitrate (10 mg). In addition courses of m onotherapy with either isosorbide dinitrate or an ACE inhibitor were c onducted using same doses of these drugs. Duration of each course was 8 weeks, It was shown that ACE inhibitors significantly potentiated an tianginal and antiischemic actions of isosorbide dinitrate. This poten tiation manifested itself mostly in prolongation of antianginal end an tiischemic effects of isosorbide dinitrate. Potentiating capacity of c aptopril and perindopril did not depend on Initial systolic blood pres sure at rest.