CHARACTERIZATION OF POLYMORPHIC FORMS OF FLUCONAZOLE USING FOURIER-TRANSFORM RAMAN-SPECTROSCOPY

Authors
GU XJ JIANG W
Citation
Xj. Gu et W. Jiang, CHARACTERIZATION OF POLYMORPHIC FORMS OF FLUCONAZOLE USING FOURIER-TRANSFORM RAMAN-SPECTROSCOPY, Journal of pharmaceutical sciences, 84(12), 1995, pp. 1438-1441
Citations number
9
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Journal of pharmaceutical sciences → ACNP
ISSN journal
00223549
Volume
84
Issue
12
Year of publication
1995
Pages
1438 - 1441
Database
ISI
SICI code
0022-3549(1995)84:12<1438:COPFOF>2.0.ZU;2-J
Abstract
Detailed Fourier transform Raman spectra of fluconazole have been reco rded and the main spectral features of fluconazole have been assigned to its vibrational modes. Two different polymorphic forms of fluconazo le were identified in two spectral regions, 150-1700 cm(-1) and 2700-3 200 cm(-1), respectively. The FT-Raman results agree well with those o f differential scanning calorimetry and X-ray powder diffractometry. T he combination pf definiteness with easy sample handling makes FT-Rama n spectroscopy a valuable technique for the analysis of polymorphs.