This article discusses the virology of Epstein-Barr virus (EBV) and pr
ovides an overview of the disease states associated with the virus, de
scribes how the immunology of EBV infection provides for control in th
e normal host, and reviews what is currently known about post-transpla
nt lymphoproliferative disorder (PTLD), including evidence for EBV in
the pathogenesis of PTLD, risk factors for its development, clinical p
resentation, methods for diagnosis, pathology, treatment, and current
and future preventive strategies.